Tissue expression of PSMF1 - Summary - The Human Protein Atlas

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PSMF1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PSMF1
Gene description	Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA041122 , HPA041300
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PSMF1 (HGNC Symbol)
Synonyms	PI31
Description	Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) (HGNC Symbol)
Entrez gene summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1113263 - 1189415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125818 (version 78.38)
Entrez gene	9491
UniProt	Q92530 (UniProt - Evidence at protein level)
neXtProt	NX_Q92530
Antibodypedia	PSMF1 antibodies

PROTEIN BROWSER

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ENST00000246015		ENST00000333082		ENST00000335877		ENST00000381898		ENST00000381899		ENST00000435720

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PSMF1-003	ENSP00000246015 ENST00000246015	Q5QPM7 Show all » « Hide Q5QPM7 [Target identity:100%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000246015} Q5QPM9 [Target identity:69%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324} F5H4Z3 [Target identity:66%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371323}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	263	29	No
PSMF1-004	ENSP00000396547 ENST00000435720		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		107	11.5	No
PSMF1-006	ENSP00000338039 ENST00000335877	Q92530 Show all » « Hide Q92530 [Direct mapping] Proteasome inhibitor PI31 subunit Q5QPM9 [Target identity:67%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070628 [proteasome binding] GO:1901799 [negative regulation of proteasomal protein catabolic process]	271	29.8	No
PSMF1-008	ENSP00000371324 ENST00000381899	Q5QPM9 Show all » « Hide Q5QPM9 [Target identity:100%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	183	20.6	No
PSMF1-010	ENSP00000371323 ENST00000381898		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		127	13.6	No
PSMF1-201	ENSP00000327704 ENST00000333082	Q92530 Show all » « Hide Q92530 [Direct mapping] Proteasome inhibitor PI31 subunit Q5QPM9 [Target identity:67%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070628 [proteasome binding] GO:1901799 [negative regulation of proteasomal protein catabolic process]	271	29.8	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx