PSMF1 - Gene info - The Human Protein Atlas

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PSMF1

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PSMF1 (HGNC Symbol)
Synonyms	PI31
Description	Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) (HGNC Symbol)
Entrez gene summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1113263 - 1189415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125818 (version 78.38)
Entrez gene	9491
UniProt	Q92530 (UniProt - Evidence at protein level)
neXtProt	NX_Q92530
Antibodypedia	PSMF1 antibodies

PROTEIN VIEW

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PSMF1-003		PSMF1-004		PSMF1-006		PSMF1-008		PSMF1-010		PSMF1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PSMF1-003	ENSP00000246015 ENST00000246015	Q5QPM7 Show all » « Hide Q5QPM7 [Target identity:100%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000246015} Q5QPM9 [Target identity:69%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324} F5H4Z3 [Target identity:66%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371323}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	263	29	No	0
PSMF1-004	ENSP00000396547 ENST00000435720		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		107	11.5	No	0
PSMF1-006	ENSP00000338039 ENST00000335877	Q92530 Show all » « Hide Q92530 [Direct mapping] Proteasome inhibitor PI31 subunit Q5QPM9 [Target identity:67%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070628 [proteasome binding] GO:1901799 [negative regulation of proteasomal protein catabolic process]	271	29.8	No	0
PSMF1-008	ENSP00000371324 ENST00000381899	Q5QPM9 Show all » « Hide Q5QPM9 [Target identity:100%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	183	20.6	No	0
PSMF1-010	ENSP00000371323 ENST00000381898		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		127	13.6	No	0
PSMF1-201	ENSP00000327704 ENST00000333082	Q92530 Show all » « Hide Q92530 [Direct mapping] Proteasome inhibitor PI31 subunit Q5QPM9 [Target identity:67%; Query identity:100%] Proteasome inhibitor PI31 subunit {ECO:0000313\|Ensembl:ENSP00000371324}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070628 [proteasome binding] GO:1901799 [negative regulation of proteasomal protein catabolic process]	271	29.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.