DIO2

GENE INFORMATION

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Gene name

DIO2 (HGNC Symbol)

Synonyms

SelY, TXDI2

Description

Deiodinase, iodothyronine, type II (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q31.1

Chromosome location (bp)

80197527 - 80387757

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000211448 (version 78.38)

Entrez gene

1734

UniProt

Q92813 (UniProt - Evidence at protein level)

neXtProt

NX_Q92813

Antibodypedia

DIO2 antibodies
 

PROTEIN VIEW

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DIO2-001
 
DIO2-002
 
DIO2-003
 
DIO2-004
 
DIO2-006
 
DIO2-007
 
DIO2-009
 
DIO2-010
 
DIO2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DIO2-001 ENSP00000451419
ENST00000557010
Q92813
Show all »
Show » Show » 273 30.6 No 1
DIO2-002 ENSP00000405854
ENST00000438257
Q92813
Show all »
Show » Show » 273 30.6 No 1
DIO2-003 ENSP00000450980
ENST00000555750
A0A024R6J8
Show all »
Show » Show » 309 34.8 No 1
DIO2-004 ENSP00000451971
ENST00000556811
Show » 58 6.5 No 0
DIO2-006 ENSP00000451136
ENST00000554188
G3V3A8
Show all »
Show » Show » 55 6.3 No 1
DIO2-007 ENSP00000451265
ENST00000553594
Show » 6 0.6 No 0
DIO2-009 ENSP00000451339
ENST00000553968
Show » 6 0.6 No 0
DIO2-010 ENSP00000450547
ENST00000557125
G3V2A7
Show all »
Show » 56 6.5 Yes 0
DIO2-201 ENSP00000411438
ENST00000422005
A0A024R6J8
Show all »
Show » Show » 145 16.6 No 1