TYMS

GENE INFORMATION

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Gene name

TYMS (HGNC Symbol)

Synonyms

HsT422, TMS, TS, Tsase

Description

Thymidylate synthetase (HGNC Symbol)

Entrez gene summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

p11.32

Chromosome location (bp)

657604 - 673578

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176890 (version 78.38)

Entrez gene

7298

UniProt

P04818 (UniProt - Evidence at protein level)

neXtProt

NX_P04818

Antibodypedia

TYMS antibodies
 

PROTEIN VIEW

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TYMS-001
 
TYMS-002
 
TYMS-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TYMS-001 ENSP00000315644
ENST00000323274
P04818
Show all »
Show » Show » 313 35.7 No 0
TYMS-002 ENSP00000314727
ENST00000323224
P04818
Show all »
Show » Show » 279 31.8 No 0
TYMS-003 ENSP00000314902
ENST00000323250
P04818
Show all »
Show » Show » 230 26.1 No 0