TPSAB1

GENE INFORMATION

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Gene name

TPSAB1 (HGNC Symbol)

Synonyms

TPS1, TPS2, TPSB1

Description

Tryptase alpha/beta 1 (HGNC Symbol)

Entrez gene summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

1240696 - 1242554

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172236 (version 78.38)

Entrez gene

7177

UniProt

Q15661 (UniProt - Evidence at protein level)

neXtProt

NX_Q15661

Antibodypedia

TPSAB1 antibodies
 

PROTEIN VIEW

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TPSAB1-001
 
TPSAB1-002
 
TPSAB1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPSAB1-001 ENSP00000343577
ENST00000338844
Q15661
Show all »
Show » Show » 275 30.5 Yes 0
TPSAB1-002 ENSP00000418247
ENST00000461509
J3QTS8
Show all »
Show » Show » 282 31.3 Yes 0
TPSAB1-004 ENSP00000456821
ENST00000561736
Q15661
Show all »
Show » Show » 213 23.9 No 0