GPT

GENE INFORMATION

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Gene name

GPT (HGNC Symbol)

Synonyms

ALT1, GPT1

Description

Glutamic-pyruvate transaminase (alanine aminotransferase) (HGNC Symbol)

Entrez gene summary

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

144502973 - 144507174

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167701 (version 78.38)

Entrez gene

2875

UniProt

P24298 (UniProt - Evidence at protein level)

neXtProt

NX_P24298

Antibodypedia

GPT antibodies
 

PROTEIN VIEW

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GPT-001
 
GPT-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPT-001 ENSP00000433586
ENST00000528431
P24298
Show all »
Show » Show » 496 54.6 No 0
GPT-201 ENSP00000378408
ENST00000394955
P24298
Show all »
Show » Show » 496 54.6 No 0