PTTG1

GENE INFORMATION

? »

Gene name

PTTG1 (HGNC Symbol)

Synonyms

EAP1, HPTTG, PTTG, securin, TUTR1

Description

Pituitary tumor-transforming 1 (HGNC Symbol)

Entrez gene summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

5

Cytoband

q33.3

Chromosome location (bp)

160421822 - 160428744

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164611 (version 78.38)

Entrez gene

9232

UniProt

O95997 (UniProt - Evidence at protein level)

neXtProt

NX_O95997

Antibodypedia

PTTG1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PTTG1-001
 
PTTG1-002
 
PTTG1-004
 
PTTG1-006
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTTG1-001 ENSP00000377536
ENST00000393964
O95997
Show all »
Show » Show » 202 22 No 0
PTTG1-002 ENSP00000344936
ENST00000352433
O95997
Show all »
Show » Show » 202 22 No 0
PTTG1-004 ENSP00000431068
ENST00000517480
E5RJR4
Show all »
Show » Show » 121 12.9 No 0
PTTG1-006 ENSP00000430642
ENST00000520452
O95997
Show all »
Show » Show » 202 22 No 0