HAND2

GENERAL INFORMATION

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Gene name

HAND2

Gene description

Heart and neural crest derivatives expressed 2

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (colon)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB025576
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon)

Organ

Expression



GENE INFORMATION

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Gene name

HAND2 (HGNC Symbol)

Synonyms

bHLHa26, dHand, Hed, Thing2

Description

Heart and neural crest derivatives expressed 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q34.1

Chromosome location (bp)

173524969 - 173530229

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164107 (version 78.38)

Entrez gene

9464

UniProt

P61296 (UniProt - Evidence at protein level)

neXtProt

NX_P61296

Antibodypedia

HAND2 antibodies


PROTEIN BROWSER

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ENST00000359562
 
ENST00000621866
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAND2-001 ENSP00000352565
ENST00000359562
P61296
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Show » Show » 217 23.7 No 0
HAND2-201 ENSP00000477638
ENST00000621866
Q494T1
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Show » Show » 186 20.7 No 0