HAND2

GENE INFORMATION

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Gene name

HAND2 (HGNC Symbol)

Synonyms

bHLHa26, dHand, Hed, Thing2

Description

Heart and neural crest derivatives expressed 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q34.1

Chromosome location (bp)

173524969 - 173530229

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164107 (version 78.38)

Entrez gene

9464

UniProt

P61296 (UniProt - Evidence at protein level)

neXtProt

NX_P61296

Antibodypedia

HAND2 antibodies
 

PROTEIN VIEW

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HAND2-001
 
HAND2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAND2-001 ENSP00000352565
ENST00000359562
P61296
Show all »
Show » Show » 217 23.7 No 0
HAND2-201 ENSP00000477638
ENST00000621866
Q494T1
Show all »
Show » Show » 186 20.7 No 0