FGFR4 - Gene info - The Human Protein Atlas

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FGFR4

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	FGFR4 (HGNC Symbol)
Synonyms	CD334, JTK2
Description	Fibroblast growth factor receptor 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	177086886 - 177098144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160867 (version 78.38)
Entrez gene	2264
UniProt	P22455 (UniProt - Evidence at protein level)
neXtProt	NX_P22455
Antibodypedia	FGFR4 antibodies

PROTEIN VIEW

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FGFR4-001		FGFR4-002		FGFR4-003		FGFR4-004		FGFR4-008		FGFR4-009		FGFR4-010		FGFR4-012		FGFR4-014

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FGFR4-001	ENSP00000292408 ENST00000292408	P22455 Show all » « Hide P22455 [Direct mapping] Fibroblast growth factor receptor 4 E7EWF4 [Target identity:25%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000424905} D6RG06 [Target identity:14%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6R9V0 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:10%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001759 [organ induction] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0030324 [lung development] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0061144 [alveolar secondary septum development] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process]	802	88	Yes	1
FGFR4-002	ENSP00000377254 ENST00000393637	P22455 Show all » « Hide P22455 [Direct mapping] Fibroblast growth factor receptor 4 E7EWF4 [Target identity:26%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000424905} D6R9V0 [Target identity:14%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RG06 [Target identity:14%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6RJD4 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process]	762	83.5	Yes	0
FGFR4-003	ENSP00000377259 ENST00000393648	J3KPQ0 Show all » « Hide J3KPQ0 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor {ECO:0000256\|PIRNR:PIRNR000628} E7EWF4 [Target identity:27%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000424905} D6RG06 [Target identity:15%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6R9V0 [Target identity:14%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	734	80.5	Yes	0
FGFR4-004	ENSP00000424960 ENST00000502906	P22455 Show all » « Hide P22455 [Direct mapping] Fibroblast growth factor receptor 4 E7EWF4 [Target identity:25%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000424905} D6RG06 [Target identity:14%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6R9V0 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:10%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process]	802	88	Yes	1
FGFR4-008	ENSP00000422889 ENST00000513166	D6R9V0 Show all » « Hide D6R9V0 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:80%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	108	11.8	Yes	0
FGFR4-009	ENSP00000427222 ENST00000510911	D6RJD4 Show all » « Hide D6RJD4 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)		87	9.5	Yes	0
FGFR4-010	ENSP00000424905 ENST00000503708	E7EWF4 Show all » « Hide E7EWF4 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000424905} D6RG06 [Target identity:56%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6R9V0 [Target identity:53%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:43%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm]	201	22.2	Yes	0
FGFR4-012	ENSP00000426492 ENST00000514472	D6RG06 Show all » « Hide D6RG06 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000426492} D6R9V0 [Target identity:94%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000422889} D6RJD4 [Target identity:76%; Query identity:100%] Fibroblast growth factor receptor 4 {ECO:0000313\|Ensembl:ENSP00000427222}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)		114	12.4	Yes	0
FGFR4-014	ENSP00000424670 ENST00000511076		Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	280	30.3	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.