FGFR4

GENERAL INFORMATION

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Gene name

FGFR4

Gene description

Fibroblast growth factor receptor 4

Protein class

Cancer-related genes
CD markers
Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Membrane,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most cell types except for mesenchymal cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 4 antibodies.
HPA027273 , HPA027369 , HPA028251 , CAB005196
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

FGFR4 (HGNC Symbol)

Synonyms

CD334, JTK2

Description

Fibroblast growth factor receptor 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.2

Chromosome location (bp)

177086886 - 177098144

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160867 (version 78.38)

Entrez gene

2264

UniProt

P22455 (UniProt - Evidence at protein level)

neXtProt

NX_P22455

Antibodypedia

FGFR4 antibodies


PROTEIN BROWSER

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ENST00000292408
 
ENST00000393637
 
ENST00000393648
 
ENST00000502906
 
ENST00000503708
 
ENST00000510911
 
ENST00000511076
 
ENST00000513166
 
ENST00000514472
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGFR4-001 ENSP00000292408
ENST00000292408
P22455
Show all »
Show » Show » 802 88 Yes 1
FGFR4-002 ENSP00000377254
ENST00000393637
P22455
Show all »
Show » Show » 762 83.5 Yes 0
FGFR4-003 ENSP00000377259
ENST00000393648
J3KPQ0
Show all »
Show » Show » 734 80.5 Yes 0
FGFR4-004 ENSP00000424960
ENST00000502906
P22455
Show all »
Show » Show » 802 88 Yes 1
FGFR4-008 ENSP00000422889
ENST00000513166
D6R9V0
Show all »
Show » Show » 108 11.8 Yes 0
FGFR4-009 ENSP00000427222
ENST00000510911
D6RJD4
Show all »
Show » 87 9.5 Yes 0
FGFR4-010 ENSP00000424905
ENST00000503708
E7EWF4
Show all »
Show » Show » 201 22.2 Yes 0
FGFR4-012 ENSP00000426492
ENST00000514472
D6RG06
Show all »
Show » 114 12.4 Yes 0
FGFR4-014 ENSP00000424670
ENST00000511076
Show » Show » 280 30.3 No 1