BAG4

GENERAL INFORMATION

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Gene name

BAG4

Gene description

BCL2-associated athanogene 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA018951 , CAB013716
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BAG4 (HGNC Symbol)

Synonyms

SODD

Description

BCL2-associated athanogene 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38176533 - 38213301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156735 (version 78.38)

Entrez gene

9530

UniProt

O95429 (UniProt - Evidence at protein level)

neXtProt

NX_O95429

Antibodypedia

BAG4 antibodies


PROTEIN BROWSER

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ENST00000287322
 
ENST00000432471
 
ENST00000521311
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAG4-001 ENSP00000287322
ENST00000287322
O95429
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Show » Show » 457 49.6 No 0
BAG4-002 ENSP00000393298
ENST00000432471
O95429
Show all »
Show » Show » 421 45.4 No 0
BAG4-004 ENSP00000430250
ENST00000521311
H0YBT1
Show all »
Show » 155 16.6 No 0