BAG4

GENE INFORMATION

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Gene name

BAG4 (HGNC Symbol)

Synonyms

SODD

Description

BCL2-associated athanogene 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38176533 - 38213301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156735 (version 78.38)

Entrez gene

9530

UniProt

O95429 (UniProt - Evidence at protein level)

neXtProt

NX_O95429

Antibodypedia

BAG4 antibodies
 

PROTEIN VIEW

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BAG4-001
 
BAG4-002
 
BAG4-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAG4-001 ENSP00000287322
ENST00000287322
O95429
Show all »
Show » Show » 457 49.6 No 0
BAG4-002 ENSP00000393298
ENST00000432471
O95429
Show all »
Show » Show » 421 45.4 No 0
BAG4-004 ENSP00000430250
ENST00000521311
H0YBT1
Show all »
Show » 155 16.6 No 0