HMGA2

GENERAL INFORMATION

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Gene name

HMGA2

Gene description

High mobility group AT-hook 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA039076 , CAB017809
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

HMGA2 (HGNC Symbol)

Synonyms

BABL, HMGIC, LIPO

Description

High mobility group AT-hook 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

65824131 - 65966295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149948 (version 78.38)

Entrez gene

8091

UniProt

P52926 (UniProt - Evidence at protein level)

neXtProt

NX_P52926

Antibodypedia

HMGA2 antibodies


PROTEIN BROWSER

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ENST00000354636
 
ENST00000393577
 
ENST00000393578
 
ENST00000403681
 
ENST00000425208
 
ENST00000536545
 
ENST00000541363
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGA2-001 ENSP00000384026
ENST00000403681
P52926
Show all »
Show » Show » 109 11.8 No 0
HMGA2-003 ENSP00000437621
ENST00000536545
F5H6H0
Show all »
Show » Show » 147 16.4 No 0
HMGA2-005 ENSP00000377206
ENST00000393578
P52926
Show all »
Show » Show » 90 9.7 No 0
HMGA2-006 ENSP00000407306
ENST00000425208
P52926
Show all »
Show » Show » 92 10.1 No 0
HMGA2-008 ENSP00000346658
ENST00000354636
P52926
Show all »
Show » Show » 106 11.5 No 0
HMGA2-011 ENSP00000439317
ENST00000541363
F5H2U8
Show all »
Show » Show » 99 10.8 No 0
HMGA2-013 ENSP00000377205
ENST00000393577
F5H2A4
Show all »
Show » Show » 118 12.7 No 0