HEY2

GENERAL INFORMATION

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Gene name

HEY2

Gene description

Hes-related family bHLH transcription factor with YRPW motif 2

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA030205
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HEY2 (HGNC Symbol)

Synonyms

bHLHb32, HERP1, HESR2

Description

Hes-related family bHLH transcription factor with YRPW motif 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q22.31

Chromosome location (bp)

125747664 - 125761269

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135547 (version 78.38)

Entrez gene

23493

UniProt

Q9UBP5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBP5

Antibodypedia

HEY2 antibodies


PROTEIN BROWSER

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ENST00000368364
 
ENST00000368365
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HEY2-001 ENSP00000357348
ENST00000368364
Q9UBP5
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Show » Show » 337 35.8 No 0
HEY2-002 ENSP00000357349
ENST00000368365
Q5TF93
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Show » Show » 291 30.8 No 0