ASL

GENERAL INFORMATION

? »

Gene name

ASL

Gene description

Argininosuccinate lyase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in hepatocytes and renal tubules.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA016646 , CAB003696
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

ASL

Synonyms

Description

Argininosuccinate lyase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q11.21

Chromosome location (bp)

66075798 - 66093558

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126522 (version 78.38)

Entrez gene

435

UniProt

P04424 (UniProt - Evidence at protein level)

neXtProt

NX_P04424

Antibodypedia

ASL antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000304874
 
ENST00000362000
 
ENST00000380839
 
ENST00000395331
 
ENST00000395332
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASL-001 ENSP00000307188
ENST00000304874
P04424
Show all »
Show » Show » 464 51.7 No 0
ASL-004 ENSP00000370219
ENST00000380839
P04424
Show all »
Show » Show » 438 48.7 No 0
ASL-005 ENSP00000378741
ENST00000395332
P04424
Show all »
Show » Show » 464 51.7 No 0
ASL-006 ENSP00000378740
ENST00000395331
P04424
Show all »
Show » Show » 444 49.5 No 0
ASL-007 ENSP00000354710
ENST00000362000
F8W943
Show all »
Show » Show » 242 27.4 No 0