PREX1

GENERAL INFORMATION

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Gene name

PREX1

Gene description

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 1 antibody.
HPA001927
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PREX1 (HGNC Symbol)

Synonyms

KIAA1415, P-REX1

Description

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

48624252 - 48827883

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124126 (version 78.38)

Entrez gene

57580

UniProt

Q8TCU6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCU6

Antibodypedia

PREX1 antibodies


PROTEIN BROWSER

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ENST00000371941
 
ENST00000620554
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PREX1-001 ENSP00000361009
ENST00000371941
Q8TCU6
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Show » Show » 1659 186.2 No 0
PREX1-004 ENSP00000481444
ENST00000620554
Show » 12 1.1 No 0