NPY

GENE INFORMATION

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Gene name

NPY (HGNC Symbol)

Synonyms

PYY4

Description

Neuropeptide Y (HGNC Symbol)

Entrez gene summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Chromosome

7

Cytoband

p15.3

Chromosome location (bp)

24284163 - 24291865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122585 (version 78.38)

Entrez gene

4852

UniProt

P01303 (UniProt - Evidence at protein level)

neXtProt

NX_P01303

Antibodypedia

NPY antibodies
 

PROTEIN VIEW

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NPY-001
 
NPY-002
 
NPY-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPY-001 ENSP00000242152
ENST00000242152
P01303
Show all »
Show » Show » 97 10.9 Yes 0
NPY-002 ENSP00000385282
ENST00000405982
P01303
Show all »
Show » Show » 97 10.9 Yes 0
NPY-003 ENSP00000384364
ENST00000407573
P01303
Show all »
Show » Show » 97 10.9 Yes 0