NDUFB3

GENERAL INFORMATION

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Gene name

NDUFB3

Gene description

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

Protein class

Mitochondrial proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate cytoplasmic positivity with a granular pattern. Strong immunoreactivity was observed in gastrointestinal tract, renal tubules, gall bladder, purkinje cells and cardiac myocytes. Remaining normal cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA034596
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NDUFB3 (HGNC Symbol)

Synonyms

B12

Description

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa (HGNC Symbol)

Entrez gene summary

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]

Chromosome

2

Cytoband

q33.1

Chromosome location (bp)

201071433 - 201085750

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119013 (version 78.38)

Entrez gene

4709

UniProt

O43676 (UniProt - Evidence at protein level)

neXtProt

NX_O43676

Antibodypedia

NDUFB3 antibodies


PROTEIN BROWSER

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ENST00000237889
 
ENST00000433898
 
ENST00000450023
 
ENST00000454214
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFB3-001 ENSP00000237889
ENST00000237889
O43676
Show all »
Show » Show » 98 11.4 No 1
NDUFB3-002 ENSP00000401834
ENST00000450023
C9JKQ2
Show all »
Show » Show » 65 7.6 No 0
NDUFB3-003 ENSP00000410600
ENST00000433898
O43676
Show all »
Show » Show » 98 11.4 No 1
NDUFB3-004 ENSP00000407336
ENST00000454214
O43676
Show all »
Show » Show » 98 11.4 No 1