Tissue expression of FOXP1 - Summary - The Human Protein Atlas

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FOXP1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	FOXP1
Gene description	Forkhead box P1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most cells.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA003876 , CAB011501
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	FOXP1 (HGNC Symbol)
Synonyms	12CC4, hFKH1B, HSPC215, QRF1
Description	Forkhead box P1 (HGNC Symbol)
Entrez gene summary	This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p13
Chromosome location (bp)	70954693 - 71583989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114861 (version 78.38)
Entrez gene	27086
UniProt	Q9H334 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H334
Antibodypedia	FOXP1 antibodies

PROTEIN BROWSER

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ENST00000318779		ENST00000318789		ENST00000468577		ENST00000472382		ENST00000475937		ENST00000484350		ENST00000485326		ENST00000491238		ENST00000493089		ENST00000497355		ENST00000497553		ENST00000498215		ENST00000610810		ENST00000614176		ENST00000615603		ENST00000622151

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
FOXP1-001	ENSP00000318902 ENST00000318789	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No
FOXP1-002	ENSP00000418524 ENST00000493089	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	676	75.2	No
FOXP1-004	ENSP00000419393 ENST00000475937	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No
FOXP1-005	ENSP00000417857 ENST00000484350	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q8IXF4 [Target identity:67%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	601	66.4	No
FOXP1-006	ENSP00000418102 ENST00000498215	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No
FOXP1-009	ENSP00000418225 ENST00000497355	H0Y882 Show all » « Hide H0Y882 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418225} Q8IXF4 [Target identity:71%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	573	64	No
FOXP1-011	ENSP00000420736 ENST00000491238	E9PFD3 Show all » « Hide E9PFD3 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000420736} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:59%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:32%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	679	76.3	No
FOXP1-012	ENSP00000418883 ENST00000468577	C9J0F0 Show all » « Hide C9J0F0 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418883} C9J5T4 [Target identity:36%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:20%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	613	68.1	No
FOXP1-014	ENSP00000318721 ENST00000318779	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	114	12.3	No
FOXP1-019	ENSP00000418784 ENST00000497553	C9IYY1 Show all » « Hide C9IYY1 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		123	14.3	No
FOXP1-020	ENSP00000484963 ENST00000472382	C9IYY1 Show all » « Hide C9IYY1 [Target identity:60%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		203	23	No
FOXP1-021	ENSP00000417941 ENST00000485326	C9J5T4 Show all » « Hide C9J5T4 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:54%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	224	25.4	No
FOXP1-023	ENSP00000479663 ENST00000610810		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		117	12.6	No
FOXP1-024	ENSP00000477918 ENST00000622151	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	114	12.3	No
FOXP1-201	ENSP00000482847 ENST00000614176	B4DMV4 Show all » « Hide B4DMV4 [Target identity:93%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:70%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:38%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:21%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	577	64.8	No
FOXP1-202	ENSP00000484803 ENST00000615603	C9J5T4 Show all » « Hide C9J5T4 [Target identity:32%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:17%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007507 [heart development] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor neuron axon guidance] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0061140 [lung secretory cell differentiation] GO:0072358 [cardiovascular system development] GO:1901249 [regulation of lung goblet cell differentiation] GO:1901250 [negative regulation of lung goblet cell differentiation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	693	77.4	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx