FOXP1 - Gene info - The Human Protein Atlas

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FOXP1

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	FOXP1 (HGNC Symbol)
Synonyms	12CC4, hFKH1B, HSPC215, QRF1
Description	Forkhead box P1 (HGNC Symbol)
Entrez gene summary	This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p13
Chromosome location (bp)	70954693 - 71583989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114861 (version 78.38)
Entrez gene	27086
UniProt	Q9H334 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H334
Antibodypedia	FOXP1 antibodies

PROTEIN VIEW

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FOXP1-001		FOXP1-002		FOXP1-004		FOXP1-005		FOXP1-006		FOXP1-009		FOXP1-011		FOXP1-012		FOXP1-014		FOXP1-019		FOXP1-020		FOXP1-021		FOXP1-023		FOXP1-024		FOXP1-201		FOXP1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXP1-001	ENSP00000318902 ENST00000318789	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No	0
FOXP1-002	ENSP00000418524 ENST00000493089	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	676	75.2	No	0
FOXP1-004	ENSP00000419393 ENST00000475937	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No	0
FOXP1-005	ENSP00000417857 ENST00000484350	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q8IXF4 [Target identity:67%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	601	66.4	No	0
FOXP1-006	ENSP00000418102 ENST00000498215	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4 {ECO:0000313\|EMBL:AAL56661.1}; Forkhead box P1, isoform CRA_a {ECO:0000313\|EMBL:EAW65489.1} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	677	75.3	No	0
FOXP1-009	ENSP00000418225 ENST00000497355	H0Y882 Show all » « Hide H0Y882 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418225} Q8IXF4 [Target identity:71%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	573	64	No	0
FOXP1-011	ENSP00000420736 ENST00000491238	E9PFD3 Show all » « Hide E9PFD3 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000420736} B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:59%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:32%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	679	76.3	No	0
FOXP1-012	ENSP00000418883 ENST00000468577	C9J0F0 Show all » « Hide C9J0F0 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418883} C9J5T4 [Target identity:36%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:20%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	613	68.1	No	0
FOXP1-014	ENSP00000318721 ENST00000318779	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	114	12.3	No	0
FOXP1-019	ENSP00000418784 ENST00000497553	C9IYY1 Show all » « Hide C9IYY1 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		123	14.3	No	0
FOXP1-020	ENSP00000484963 ENST00000472382	C9IYY1 Show all » « Hide C9IYY1 [Target identity:60%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		203	23	No	0
FOXP1-021	ENSP00000417941 ENST00000485326	C9J5T4 Show all » « Hide C9J5T4 [Target identity:100%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:54%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	224	25.4	No	0
FOXP1-023	ENSP00000479663 ENST00000610810		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		117	12.6	No	0
FOXP1-024	ENSP00000477918 ENST00000622151	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]	114	12.3	No	0
FOXP1-201	ENSP00000482847 ENST00000614176	B4DMV4 Show all » « Hide B4DMV4 [Target identity:93%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 {ECO:0000313\|EMBL:BAG60016.1} Q8IXF4 [Target identity:70%; Query identity:100%] Fork head-related protein like B {ECO:0000313\|EMBL:BAC53800.1} C9J5T4 [Target identity:38%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:21%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	577	64.8	No	0
FOXP1-202	ENSP00000484803 ENST00000615603	C9J5T4 Show all » « Hide C9J5T4 [Target identity:32%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000417941} C9IYY1 [Target identity:17%; Query identity:100%] Forkhead box protein P1 {ECO:0000313\|Ensembl:ENSP00000418784}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007507 [heart development] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor neuron axon guidance] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0061140 [lung secretory cell differentiation] GO:0072358 [cardiovascular system development] GO:1901249 [regulation of lung goblet cell differentiation] GO:1901250 [negative regulation of lung goblet cell differentiation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	693	77.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.