PDE10A

GENERAL INFORMATION

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Gene name

PDE10A

Gene description

Phosphodiesterase 10A

Protein class

Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (thyroid gland)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Staining of neuropil in lateral ventricle.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA047200 , CAB045998
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

PDE10A

Synonyms

Description

Phosphodiesterase 10A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Chromosome

6

Cytoband

q27

Chromosome location (bp)

165327287 - 165986603

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112541 (version 78.38)

Entrez gene

10846

UniProt

Q9Y233 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y233

Antibodypedia

PDE10A antibodies


PROTEIN BROWSER

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ENST00000366882
 
ENST00000539869
 
ENST00000616273
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDE10A-001 ENSP00000355847
ENST00000366882
Q9Y233
Show all »
Show » Show » 779 88.4 No 0
PDE10A-002 ENSP00000438284
ENST00000539869
Q9Y233
Show all »
Show » Show » 789 89.4 No 0
PDE10A-201 ENSP00000478556
ENST00000616273
Show » 183 19.3 No 0