MADD

GENE INFORMATION

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Gene name

MADD (HGNC Symbol)

Synonyms

DENN, KIAA0358, RAB3GEP

Description

MAP-kinase activating death domain (HGNC Symbol)

Entrez gene summary

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

47269161 - 47330031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110514 (version 78.38)

Entrez gene

8567

UniProt

Q8WXG6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WXG6

Antibodypedia

MADD antibodies
 

PROTEIN VIEW

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 « 
 
MADD-001
 
MADD-002
 
MADD-003
 
MADD-004
 
MADD-005
 
MADD-006
 
MADD-007
 
MADD-009
 
MADD-010
 
MADD-011
 
MADD-012
 
MADD-013
 
MADD-018
 
MADD-023
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MADD-001 ENSP00000343902
ENST00000342922
C9J6B0
Show all »
Show » 1588 176.6 No 1
MADD-002 ENSP00000385585
ENST00000402799
Q8WXG6
Show all »
Show » Show » 1545 171.4 No 1
MADD-003 ENSP00000384435
ENST00000406482
Q8WXG6
Show all »
Show » Show » 1479 164 No 1
MADD-004 ENSP00000378745
ENST00000395336
Q8WXG6
Show all »
Show » Show » 1581 175.9 No 1
MADD-005 ENSP00000304505
ENST00000349238
Q8WXG6
Show all »
Show » Show » 1608 178.6 No 1
MADD-006 ENSP00000310933
ENST00000311027
Q8WXG6
Show all »
Show » Show » 1647 183.3 No 1
MADD-007 ENSP00000384204
ENST00000407859
Q8WXG6
Show all »
Show » Show » 1565 173.4 No 1
MADD-009 ENSP00000384287
ENST00000402192
Q8WXG6
Show all »
Show » Show » 1587 176.5 No 1
MADD-010 ENSP00000388255
ENST00000453571
C9JM97
Show all »
Show » 75 8.7 No 0
MADD-011 ENSP00000413116
ENST00000444117
C9K0L0
Show all »
Show » 136 15.2 No 0
MADD-012 ENSP00000398167
ENST00000428807
C9J6B0
Show all »
Show » 154 17.4 No 2
MADD-013 ENSP00000402364
ENST00000422579
C9JLZ9
Show all »
Show » 135 15.2 No 0
MADD-018 ENSP00000384483
ENST00000405573
F8W8U2
Show all »
Show » Show » 439 49.1 No 0
MADD-023 ENSP00000378753
ENST00000395344
Q8WXG6
Show all »
Show » Show » 1541 171 No 1