MTMR3

GENERAL INFORMATION

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Gene name

MTMR3

Gene description

Myotubularin related protein 3

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues, most abundant in basal cells in seminiferus ducts.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA034515 , HPA034516
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MTMR3 (HGNC Symbol)

Synonyms

FYVE-DSP1, KIAA0371, ZFYVE10

Description

Myotubularin related protein 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

29883155 - 30030866

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100330 (version 78.38)

Entrez gene

8897

UniProt

Q13615 (UniProt - Evidence at protein level)

neXtProt

NX_Q13615

Antibodypedia

MTMR3 antibodies


PROTEIN BROWSER

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ENST00000323630
 
ENST00000333027
 
ENST00000351488
 
ENST00000401950
 
ENST00000406629
 
ENST00000445401
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTMR3-001 ENSP00000384651
ENST00000401950
Q13615
Show all »
Show » Show » 1198 133.6 No 0
MTMR3-002 ENSP00000307271
ENST00000351488
Q13615
Show all »
Show » Show » 1161 129.4 No 0
MTMR3-003 ENSP00000384077
ENST00000406629
Q13615
Show all »
Show » Show » 1170 130.6 No 0
MTMR3-004 ENSP00000318070
ENST00000323630
G5E953
Show all »
Show » Show » 1062 117.6 No 0
MTMR3-006 ENSP00000409063
ENST00000445401
C9JLU3
Show all »
Show » 139 16.4 No 0
MTMR3-201 ENSP00000331649
ENST00000333027
Q13615
Show all »
Show » Show » 1170 130.6 No 0