SOX10

GENE INFORMATION

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Gene name

SOX10 (HGNC Symbol)

Synonyms

DOM, WS2E, WS4

Description

SRY (sex determining region Y)-box 10 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

37970686 - 37987422

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100146 (version 78.38)

Entrez gene

6663

UniProt

P56693 (UniProt - Evidence at protein level)

neXtProt

NX_P56693

Antibodypedia

SOX10 antibodies
 

PROTEIN VIEW

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SOX10-001
 
SOX10-002
 
SOX10-003
 
SOX10-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX10-001 ENSP00000354130
ENST00000360880
P56693
Show all »
Show » Show » 466 49.9 No 0
SOX10-002 ENSP00000380093
ENST00000396884
P56693
Show all »
Show » Show » 466 49.9 No 0
SOX10-003 ENSP00000414853
ENST00000427770
A6PVD3
Show all »
Show » 213 23.3 No 0
SOX10-004 ENSP00000399777
ENST00000446929
Show » 179 19.7 No 0