SOX10

GENERAL INFORMATION

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Gene name

SOX10

Gene description

SRY (sex determining region Y)-box 10

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, salivary gland, skin)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in glial cells, peripheral nerve and salivary gland.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB003171
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, salivary gland, skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SOX10 (HGNC Symbol)

Synonyms

DOM, WS2E, WS4

Description

SRY (sex determining region Y)-box 10 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

37970686 - 37987422

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100146 (version 78.38)

Entrez gene

6663

UniProt

P56693 (UniProt - Evidence at protein level)

neXtProt

NX_P56693

Antibodypedia

SOX10 antibodies


PROTEIN BROWSER

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ENST00000360880
 
ENST00000396884
 
ENST00000427770
 
ENST00000446929
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX10-001 ENSP00000354130
ENST00000360880
P56693
Show all »
Show » Show » 466 49.9 No 0
SOX10-002 ENSP00000380093
ENST00000396884
P56693
Show all »
Show » Show » 466 49.9 No 0
SOX10-003 ENSP00000414853
ENST00000427770
A6PVD3
Show all »
Show » 213 23.3 No 0
SOX10-004 ENSP00000399777
ENST00000446929
Show » 179 19.7 No 0