CRKL

GENERAL INFORMATION

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Gene name

CRKL

Gene description

V-crk avian sarcoma virus CT10 oncogene homolog-like

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A sub-set of glandular cells of the gastrointestinal tract showed strong positivity. Gall bladder, exocrine pancreas, urothelia, seminal vesicle, epididymis, trophoblats in placenta and lymphoid cells outside reaction centra showed moderate cytoplasmic positivity. Remaining normal cells were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001100
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CRKL

Synonyms

Description

V-crk avian sarcoma virus CT10 oncogene homolog-like (HGNC Symbol)

Entrez gene summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

20917426 - 20953749

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099942 (version 78.38)

Entrez gene

1399

UniProt

P46109 (UniProt - Evidence at protein level)

neXtProt

NX_P46109

Antibodypedia

CRKL antibodies


PROTEIN BROWSER

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ENST00000354336
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRKL-001 ENSP00000346300
ENST00000354336
P46109
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