CRKL

GENE INFORMATION

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Gene name

CRKL

Synonyms

Description

V-crk avian sarcoma virus CT10 oncogene homolog-like (HGNC Symbol)

Entrez gene summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

20917426 - 20953749

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099942 (version 78.38)

Entrez gene

1399

UniProt

P46109 (UniProt - Evidence at protein level)

neXtProt

NX_P46109

Antibodypedia

CRKL antibodies
 

PROTEIN VIEW

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CRKL-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRKL-001 ENSP00000346300
ENST00000354336
P46109
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