Tissue expression of CAPN3 - Summary - The Human Protein Atlas

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CAPN3

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CAPN3
Gene description	Calpain 3, (p94)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enhanced (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues, most abundant in muscle cells.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA040052 , CAB033438
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enhanced (skeletal muscle)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enriched (skeletal muscle)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CAPN3 (HGNC Symbol)
Synonyms	CANP3, LGMD2, LGMD2A, nCL-1, p94
Description	Calpain 3, (p94) (HGNC Symbol)
Entrez gene summary	Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	42359500 - 42412318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092529 (version 78.38)
Entrez gene	825
UniProt	P20807 (UniProt - Evidence at protein level)
neXtProt	NX_P20807
Antibodypedia	CAPN3 antibodies

PROTEIN BROWSER

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ENST00000318023		ENST00000337571		ENST00000349748		ENST00000356316		ENST00000357568		ENST00000397163		ENST00000397200		ENST00000397204		ENST00000561817		ENST00000564503		ENST00000565559		ENST00000567071		ENST00000569136		ENST00000569827

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
CAPN3-005	ENSP00000183936 ENST00000349748	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BMH1 [Target identity:34%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000454379} H3BS30 [Target identity:12%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	729	84.1	No
CAPN3-006	ENSP00000336840 ENST00000337571	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No
CAPN3-007	ENSP00000380384 ENST00000397200	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:30%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	309	35.9	No
CAPN3-008	ENSP00000350181 ENST00000357568	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:11%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	815	93.5	No
CAPN3-009	ENSP00000380349 ENST00000397163	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:11%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001896 [autolysis] GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045661 [regulation of myoblast differentiation] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0070315 [G1 to G0 transition involved in cell differentiation] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	821	94.3	No
CAPN3-010	ENSP00000454379 ENST00000569827	H3BMH1 Show all » « Hide H3BMH1 [Target identity:99%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000454379}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	256	29.9	No
CAPN3-011	ENSP00000456607 ENST00000567071		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		188	21.5	No
CAPN3-012	ENSP00000380387 ENST00000397204	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No
CAPN3-013	ENSP00000456575 ENST00000561817	H3BS77 Show all » « Hide H3BS77 [Target identity:100%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456575} A4FTZ9 [Target identity:91%; Query identity:100%] CAPN3 protein {ECO:0000313\|EMBL:AAI00784.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	191	22	No
CAPN3-015	ENSP00000455254 ENST00000569136	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No
CAPN3-017	ENSP00000457878 ENST00000565559	H3BUZ3 Show all » « Hide H3BUZ3 [Target identity:100%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000457878}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	157	17.6	No
CAPN3-019	ENSP00000457898 ENST00000564503		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding]	169	19.5	No
CAPN3-201	ENSP00000326281 ENST00000318023	H3BS30 Show all » « Hide H3BS30 [Target identity:12%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis]	773	89	No
CAPN3-202	ENSP00000348667 ENST00000356316	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx