Tissue expression of RPS6KA2 - Summary - The Human Protein Atlas

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RPS6KA2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	RPS6KA2
Gene description	Ribosomal protein S6 kinase, 90kDa, polypeptide 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression. The annotation is based on antibodies recognizing more than one splice variant. One (or several) antibodies may recognize alternative forms and therefore show a different staining pattern.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 4 antibodies. HPA045061 , HPA054237 , CAB026243 , CAB069428
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	RPS6KA2 (HGNC Symbol)
Synonyms	HU-2, RSK, RSK3
Description	Ribosomal protein S6 kinase, 90kDa, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	166409364 - 166906451
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071242 (version 78.38)
Entrez gene	6196
UniProt	Q15349 (UniProt - Evidence at protein level)
neXtProt	NX_Q15349
Antibodypedia	RPS6KA2 antibodies

PROTEIN BROWSER

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ENST00000265678		ENST00000405189		ENST00000481261		ENST00000503859		ENST00000506565		ENST00000507350		ENST00000507371		ENST00000510118		ENST00000511034		ENST00000512860

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
RPS6KA2-001	ENSP00000265678 ENST00000265678	Q15349 Show all » « Hide Q15349 [Direct mapping] Ribosomal protein S6 kinase alpha-2 B7Z3B5 [Target identity:87%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313\|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|EMBL:BAH12151.1} D6R910 [Target identity:17%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:13%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:4%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008285 [negative regulation of cell proliferation] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031965 [nuclear membrane] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035556 [intracellular signal transduction] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0045786 [negative regulation of cell cycle] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051403 [stress-activated MAPK cascade]	733	83.2	No
RPS6KA2-003	ENSP00000427015 ENST00000503859	Q15349 Show all » « Hide Q15349 [Direct mapping] Ribosomal protein S6 kinase alpha-2 B7Z3B5 [Target identity:86%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313\|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|EMBL:BAH12151.1} D6R910 [Target identity:16%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:12%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:4%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0001556 [oocyte maturation] GO:0002035 [brain renin-angiotensin system] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004711 [ribosomal protein S6 kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007507 [heart development] GO:0008285 [negative regulation of cell proliferation] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0010628 [positive regulation of gene expression] GO:0010659 [cardiac muscle cell apoptotic process] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0018105 [peptidyl-serine phosphorylation] GO:0031965 [nuclear membrane] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035556 [intracellular signal transduction] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0045786 [negative regulation of cell cycle] GO:0045835 [negative regulation of meiosis] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051403 [stress-activated MAPK cascade] GO:0060047 [heart contraction] GO:0070613 [regulation of protein processing] GO:0071322 [cellular response to carbohydrate stimulus]	741	84	No
RPS6KA2-005	ENSP00000422435 ENST00000510118	F2Z2J1 Show all » « Hide F2Z2J1 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase {ECO:0000256\|PIRNR:PIRNR000606} B7Z3B5 [Target identity:84%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313\|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|EMBL:BAH12151.1} D6RE03 [Target identity:22%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425148} D6R910 [Target identity:16%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:12%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:4%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031965 [nuclear membrane] GO:0035556 [intracellular signal transduction]	758	85.6	No
RPS6KA2-006	ENSP00000422484 ENST00000481261	B7Z3B5 Show all » « Hide B7Z3B5 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313\|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|EMBL:BAH12151.1} D6R910 [Target identity:19%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:14%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:5%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031965 [nuclear membrane]	644	73.1	No
RPS6KA2-007	ENSP00000386050 ENST00000405189	B7Z3B5 Show all » « Hide B7Z3B5 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313\|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|EMBL:BAH12151.1} D6R910 [Target identity:19%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:14%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:5%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031965 [nuclear membrane]	644	73.1	No
RPS6KA2-009	ENSP00000425148 ENST00000506565	D6RE03 Show all » « Hide D6RE03 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425148} D6RD75 [Target identity:21%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	171	19.2	No
RPS6KA2-010	ENSP00000427605 ENST00000512860	D6RHW7 Show all » « Hide D6RHW7 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:37%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	96	11.3	No
RPS6KA2-011	ENSP00000423114 ENST00000507371	D6RA62 Show all » « Hide D6RA62 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000423114} D6RD75 [Target identity:25%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	141	16.4	No
RPS6KA2-012	ENSP00000425458 ENST00000511034	D6RD75 Show all » « Hide D6RD75 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016772 [transferase activity, transferring phosphorus-containing groups]	36	4.3	No
RPS6KA2-013	ENSP00000422197 ENST00000507350	D6R910 Show all » « Hide D6R910 [Target identity:100%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000422197} D6RHW7 [Target identity:76%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000427605} D6RD75 [Target identity:28%; Query identity:100%] Ribosomal protein S6 kinase alpha-2 {ECO:0000313\|Ensembl:ENSP00000425458}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	125	14.6	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx