RPS6KA2 - Gene info - The Human Protein Atlas

Gene name

RPS6KA2 (HGNC Symbol)

Synonyms

HU-2, RSK, RSK3

Description

Ribosomal protein S6 kinase, 90kDa, polypeptide 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q27

Chromosome location (bp)

166409364 - 166906451

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000071242 (version 78.38)

Entrez gene

6196

UniProt

Q15349 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPS6KA2-001

ENSP00000265678
ENST00000265678

Q15349
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Q15349 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
B7Z3B5 [Target identity:87%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313|EMBL:BAH12151.1}
D6R910 [Target identity:17%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000422197}
D6RHW7 [Target identity:13%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:4%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031965 [nuclear membrane]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045786 [negative regulation of cell cycle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]

733

83.2

RPS6KA2-003

ENSP00000427015
ENST00000503859

Q15349
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Q15349 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
B7Z3B5 [Target identity:86%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313|EMBL:BAH12151.1}
D6R910 [Target identity:16%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000422197}
D6RHW7 [Target identity:12%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:4%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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GO:0000287 [magnesium ion binding]
GO:0001556 [oocyte maturation]
GO:0002035 [brain renin-angiotensin system]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0010628 [positive regulation of gene expression]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031965 [nuclear membrane]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045786 [negative regulation of cell cycle]
GO:0045835 [negative regulation of meiosis]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0060047 [heart contraction]
GO:0070613 [regulation of protein processing]
GO:0071322 [cellular response to carbohydrate stimulus]

741

RPS6KA2-005

ENSP00000422435
ENST00000510118

F2Z2J1
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F2Z2J1 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase {ECO:0000256|PIRNR:PIRNR000606}
B7Z3B5 [Target identity:84%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313|EMBL:BAH12151.1}
D6RE03 [Target identity:22%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425148}
D6R910 [Target identity:16%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000422197}
D6RHW7 [Target identity:12%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:4%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005840 [ribosome]
GO:0006468 [protein phosphorylation]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]

758

85.6

RPS6KA2-006

ENSP00000422484
ENST00000481261

B7Z3B5
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B7Z3B5 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000386050}; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a {ECO:0000313|EMBL:EAW47522.1}; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 {ECO:0000313|EMBL:BAH12151.1}
D6R910 [Target identity:19%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000422197}
D6RHW7 [Target identity:14%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:5%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005840 [ribosome]
GO:0006468 [protein phosphorylation]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031965 [nuclear membrane]

644

73.1

RPS6KA2-007

ENSP00000386050
ENST00000405189

B7Z3B5
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644

73.1

RPS6KA2-009

ENSP00000425148
ENST00000506565

D6RE03
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D6RE03 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425148}
D6RD75 [Target identity:21%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

171

19.2

RPS6KA2-010

ENSP00000427605
ENST00000512860

D6RHW7
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D6RHW7 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:37%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

11.3

RPS6KA2-011

ENSP00000423114
ENST00000507371

D6RA62
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D6RA62 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000423114}
D6RD75 [Target identity:25%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

141

16.4

RPS6KA2-012

ENSP00000425458
ENST00000511034

D6RD75
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D6RD75 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0016772 [transferase activity, transferring phosphorus-containing groups]

4.3

RPS6KA2-013

ENSP00000422197
ENST00000507350

D6R910
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D6R910 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000422197}
D6RHW7 [Target identity:76%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000427605}
D6RD75 [Target identity:28%; Query identity:100%]
Ribosomal protein S6 kinase alpha-2 {ECO:0000313|Ensembl:ENSP00000425458}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

125

14.6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.