GLRX2

GENERAL INFORMATION

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Gene name

GLRX2

Gene description

Glutaredoxin 2

Protein class

Mitochondrial proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA023087
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

GLRX2 (HGNC Symbol)

Synonyms

bA101E13.1, GRX2

Description

Glutaredoxin 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

q31.2

Chromosome location (bp)

193096468 - 193106114

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023572 (version 78.38)

Entrez gene

51022

UniProt

Q9NS18 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS18

Antibodypedia

GLRX2 antibodies


PROTEIN BROWSER

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ENST00000367439
 
ENST00000367440
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLRX2-001 ENSP00000356409
ENST00000367439
Q9NS18
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Show » Show » 164 18.1 No 0
GLRX2-002 ENSP00000356410
ENST00000367440
Q9NS18
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Show » Show » 165 18.7 No 0