GLRX2

GENE INFORMATION

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Gene name

GLRX2 (HGNC Symbol)

Synonyms

bA101E13.1, GRX2

Description

Glutaredoxin 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

q31.2

Chromosome location (bp)

193096468 - 193106114

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023572 (version 78.38)

Entrez gene

51022

UniProt

Q9NS18 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS18

Antibodypedia

GLRX2 antibodies
 

PROTEIN VIEW

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GLRX2-001
 
GLRX2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLRX2-001 ENSP00000356409
ENST00000367439
Q9NS18
Show all »
Show » Show » 164 18.1 No 0
GLRX2-002 ENSP00000356410
ENST00000367440
Q9NS18
Show all »
Show » Show » 165 18.7 No 0