CD4

GENERAL INFORMATION

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Gene name

CD4

Gene description

CD4 molecule

Protein class

CD markers
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in peripheral lymphocytes and subsets of cells in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA004252 , HPA004472 , CAB000011 , CAB068180
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CD4

Synonyms

Description

CD4 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6786858 - 6820808

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010610 (version 78.38)

Entrez gene

920

UniProt

P01730 (UniProt - Evidence at protein level)

neXtProt

NX_P01730

Antibodypedia

CD4 antibodies


PROTEIN BROWSER

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ENST00000011653
 
ENST00000539492
 
ENST00000541982
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD4-001 ENSP00000011653
ENST00000011653
P01730
Show all »
Show » Show » 458 51.1 Yes 1
CD4-005 ENSP00000445167
ENST00000541982
F5H480
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Show » Show » 148 16.5 No 0
CD4-007 ENSP00000440720
ENST00000539492
F5GYA9
Show all »
Show » 45 4.8 Yes 0