CD4

GENE INFORMATION

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Gene name

CD4

Synonyms

Description

CD4 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6786858 - 6820808

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010610 (version 78.38)

Entrez gene

920

UniProt

P01730 (UniProt - Evidence at protein level)

neXtProt

NX_P01730

Antibodypedia

CD4 antibodies
 

PROTEIN VIEW

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CD4-001
 
CD4-005
 
CD4-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD4-001 ENSP00000011653
ENST00000011653
P01730
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Show » Show » 458 51.1 Yes 1
CD4-005 ENSP00000445167
ENST00000541982
F5H480
Show all »
Show » Show » 148 16.5 No 0
CD4-007 ENSP00000440720
ENST00000539492
F5GYA9
Show all »
Show » 45 4.8 Yes 0