CHEK1 - Gene info - The Human Protein Atlas

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CHEK1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CHEK1 (HGNC Symbol)
Synonyms	CHK1
Description	Checkpoint kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125625136 - 125676255
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149554 (version 78.38)
Entrez gene	1111
UniProt	O14757 (UniProt - Evidence at protein level)
neXtProt	NX_O14757
Antibodypedia	CHEK1 antibodies

PROTEIN VIEW

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CHEK1-001		CHEK1-002		CHEK1-004		CHEK1-005		CHEK1-006		CHEK1-007		CHEK1-008		CHEK1-009		CHEK1-010		CHEK1-011		CHEK1-012		CHEK1-013		CHEK1-201		CHEK1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CHEK1-001	ENSP00000391090 ENST00000427383	E7EPP6 Show all » « Hide E7EPP6 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000391090}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0043231 [intracellular membrane-bounded organelle]	492	55.5	No	0
CHEK1-002	ENSP00000412504 ENST00000428830	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No	0
CHEK1-004	ENSP00000435371 ENST00000534070	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No	0
CHEK1-005	ENSP00000442317 ENST00000544373	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	382	43.7	No	0
CHEK1-006	ENSP00000278916 ENST00000278916	J3KN87 Show all » « Hide J3KN87 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000278916} E9PKQ3 [Target identity:47%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:39%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:30%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:29%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:9%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0043231 [intracellular membrane-bounded organelle]	432	49	No	0
CHEK1-007	ENSP00000432890 ENST00000524737	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No	0
CHEK1-008	ENSP00000432470 ENST00000534685	E9PQW7 Show all » « Hide E9PQW7 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:33%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:16%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	127	14.4	No	0
CHEK1-009	ENSP00000433103 ENST00000533778	E9PM65 Show all » « Hide E9PM65 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:50%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	42	4.6	No	0
CHEK1-010	ENSP00000431815 ENST00000526937	E9PJI4 Show all » « Hide E9PJI4 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:78%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:74%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:24%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:12%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	170	19.5	No	0
CHEK1-011	ENSP00000431525 ENST00000527013	E9PKQ3 Show all » « Hide E9PKQ3 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:83%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:65%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:62%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:20%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:10%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	204	23.3	No	0
CHEK1-012	ENSP00000477588 ENST00000531607		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	111	12.9	No	0
CHEK1-013	ENSP00000434646 ENST00000532669	E9PPA5 Show all » « Hide E9PPA5 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434646}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	192	22.2	No	0
CHEK1-201	ENSP00000388648 ENST00000438015	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005657 [replication fork] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010468 [regulation of gene expression] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0035407 [histone H3-T11 phosphorylation] GO:0042127 [regulation of cell proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0071310 [cellular response to organic substance] GO:0071313 [cellular response to caffeine] GO:0090399 [replicative senescence] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No	0
CHEK1-202	ENSP00000481616 ENST00000532449	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:46%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:38%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:30%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:28%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:9%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	442	50.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.