Tissue expression of CHEK1 - Summary - The Human Protein Atlas

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CHEK1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CHEK1
Gene description	Checkpoint kinase 1
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (testis)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CHEK1 (HGNC Symbol)
Synonyms	CHK1
Description	Checkpoint kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125625136 - 125676255
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149554 (version 78.38)
Entrez gene	1111
UniProt	O14757 (UniProt - Evidence at protein level)
neXtProt	NX_O14757
Antibodypedia	CHEK1 antibodies

PROTEIN BROWSER

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ENST00000278916		ENST00000427383		ENST00000428830		ENST00000438015		ENST00000524737		ENST00000526937		ENST00000527013		ENST00000531607		ENST00000532449		ENST00000532669		ENST00000533778		ENST00000534070		ENST00000534685		ENST00000544373

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
CHEK1-001	ENSP00000391090 ENST00000427383	E7EPP6 Show all » « Hide E7EPP6 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000391090}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0043231 [intracellular membrane-bounded organelle]	492	55.5	No
CHEK1-002	ENSP00000412504 ENST00000428830	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No
CHEK1-004	ENSP00000435371 ENST00000534070	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No
CHEK1-005	ENSP00000442317 ENST00000544373	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	382	43.7	No
CHEK1-006	ENSP00000278916 ENST00000278916	J3KN87 Show all » « Hide J3KN87 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000278916} E9PKQ3 [Target identity:47%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:39%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:30%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:29%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:9%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0043231 [intracellular membrane-bounded organelle]	432	49	No
CHEK1-007	ENSP00000432890 ENST00000524737	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No
CHEK1-008	ENSP00000432470 ENST00000534685	E9PQW7 Show all » « Hide E9PQW7 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:33%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:16%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	127	14.4	No
CHEK1-009	ENSP00000433103 ENST00000533778	E9PM65 Show all » « Hide E9PM65 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:50%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	42	4.6	No
CHEK1-010	ENSP00000431815 ENST00000526937	E9PJI4 Show all » « Hide E9PJI4 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:78%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:74%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:24%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:12%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	170	19.5	No
CHEK1-011	ENSP00000431525 ENST00000527013	E9PKQ3 Show all » « Hide E9PKQ3 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:83%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:65%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:62%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:20%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:10%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	204	23.3	No
CHEK1-012	ENSP00000477588 ENST00000531607		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	111	12.9	No
CHEK1-013	ENSP00000434646 ENST00000532669	E9PPA5 Show all » « Hide E9PPA5 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434646}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	192	22.2	No
CHEK1-201	ENSP00000388648 ENST00000438015	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:42%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:35%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:27%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:8%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005657 [replication fork] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010468 [regulation of gene expression] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0035407 [histone H3-T11 phosphorylation] GO:0042127 [regulation of cell proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0071310 [cellular response to organic substance] GO:0071313 [cellular response to caffeine] GO:0090399 [replicative senescence] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000615 [regulation of histone H3-K9 acetylation]	476	54.4	No
CHEK1-202	ENSP00000481616 ENST00000532449	O14757 Show all » « Hide O14757 [Direct mapping] Serine/threonine-protein kinase Chk1 E9PKQ3 [Target identity:46%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431525} E9PJI4 [Target identity:38%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000431815} E9PRU7 [Target identity:30%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000434141} E9PQW7 [Target identity:28%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000432470} E9PM65 [Target identity:9%; Query identity:100%] Serine/threonine-protein kinase Chk1 {ECO:0000313\|Ensembl:ENSP00000433103} Q6W8P8 [Target identity:4%; Query identity:100%] CHEK1 {ECO:0000313\|EMBL:AAQ76038.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000781 [chromosome, telomeric region] GO:0000785 [chromatin] GO:0000794 [condensed nuclear chromosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0010569 [regulation of double-strand break repair via homologous recombination] GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018107 [peptidyl-threonine phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0035402 [histone kinase activity (H3-T11 specific)] GO:0043231 [intracellular membrane-bounded organelle] GO:0045839 [negative regulation of mitosis] GO:0046602 [regulation of mitotic centrosome separation] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071260 [cellular response to mechanical stimulus] GO:0090399 [replicative senescence] GO:2000615 [regulation of histone H3-K9 acetylation]	442	50.4	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx