ARNT

GENERAL INFORMATION

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Gene name

ARNT

Gene description

Aryl hydrocarbon receptor nuclear translocator

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA001759 , CAB004318
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ARNT (HGNC Symbol)

Synonyms

bHLHe2, HIF-1beta

Description

Aryl hydrocarbon receptor nuclear translocator (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

150809705 - 150876768

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143437 (version 78.38)

Entrez gene

405

UniProt

P27540 (UniProt - Evidence at protein level)

neXtProt

NX_P27540

Antibodypedia

ARNT antibodies


PROTEIN BROWSER

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ENST00000354396
 
ENST00000358595
 
ENST00000505755
 
ENST00000515192
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARNT-001 ENSP00000351407
ENST00000358595
P27540
Show all »
Show » Show » 789 86.6 No 0
ARNT-006 ENSP00000423851
ENST00000515192
P27540
Show all »
Show » Show » 775 85.3 No 0
ARNT-009 ENSP00000427571
ENST00000505755
P27540
Show all »
Show » Show » 774 84.9 No 0
ARNT-010 ENSP00000346372
ENST00000354396
P27540
Show all »
Show » Show » 787 86.4 No 0