ARNT

GENE INFORMATION

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Gene name

ARNT (HGNC Symbol)

Synonyms

bHLHe2, HIF-1beta

Description

Aryl hydrocarbon receptor nuclear translocator (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

150809705 - 150876768

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143437 (version 78.38)

Entrez gene

405

UniProt

P27540 (UniProt - Evidence at protein level)

neXtProt

NX_P27540

Antibodypedia

ARNT antibodies
 

PROTEIN VIEW

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ARNT-001
 
ARNT-006
 
ARNT-009
 
ARNT-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARNT-001 ENSP00000351407
ENST00000358595
P27540
Show all »
Show » Show » 789 86.6 No 0
ARNT-006 ENSP00000423851
ENST00000515192
P27540
Show all »
Show » Show » 775 85.3 No 0
ARNT-009 ENSP00000427571
ENST00000505755
P27540
Show all »
Show » Show » 774 84.9 No 0
ARNT-010 ENSP00000346372
ENST00000354396
P27540
Show all »
Show » Show » 787 86.4 No 0