CRYAA

GENE INFORMATION

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Gene name

CRYAA (HGNC Symbol)

Synonyms

CRYA1, HSPB4

Description

Crystallin, alpha A (HGNC Symbol)

Entrez gene summary

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]

Chromosome

21

Cytoband

p12

Chromosome location (bp)

6560714 - 6564489

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000276076 (version 78.38)

Entrez gene

1409

UniProt

neXtProt

Antibodypedia

CRYAA antibodies
 

PROTEIN VIEW

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CRYAA-001
 
CRYAA-002
 
CRYAA-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRYAA-001 ENSP00000482816
ENST00000619537
Q71V83
Show all »
Show » Show » 173 19.9 No 0
CRYAA-002 ENSP00000485653
ENST00000624019
Q71V83
Show all »
Show » 127 14.3 No 0
CRYAA-003 ENSP00000485302
ENST00000624932
E9PHE4
Show all »
Show » Show » 136 15.3 No 0