ORAI1

GENE INFORMATION

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Gene name

ORAI1 (HGNC Symbol)

Synonyms

CRACM1, FLJ14466, TMEM142A

Description

ORAI calcium release-activated calcium modulator 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

121626550 - 121642677

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000276045 (version 78.38)

Entrez gene

84876

UniProt

Q96D31 (UniProt - Evidence at protein level)

neXtProt

NX_Q96D31

Antibodypedia

ORAI1 antibodies
 

PROTEIN VIEW

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ORAI1-001
 
ORAI1-002
 
ORAI1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ORAI1-001 ENSP00000482568
ENST00000617316
Show » 238 26.1 Yes 3
ORAI1-002 ENSP00000477953
ENST00000611718
Show » 89 9.2 Yes 0
ORAI1-201 ENSP00000480616
ENST00000616379
Q96D31
Show all »
Show » Show » 301 32.7 No 3