UHRF1

GENERAL INFORMATION

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Gene name

UHRF1

Gene description

Ubiquitin-like with PHD and ring finger domains 1

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression



GENE INFORMATION

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Gene name

UHRF1 (HGNC Symbol)

Synonyms

FLJ21925, ICBP90, Np95, RNF106

Description

Ubiquitin-like with PHD and ring finger domains 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

4903080 - 4962154

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000276043 (version 78.38)

Entrez gene

29128

UniProt

Q96T88 (UniProt - Evidence at protein level)

neXtProt

NX_Q96T88

Antibodypedia

UHRF1 antibodies


PROTEIN BROWSER

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ENST00000612630
 
ENST00000613817
 
ENST00000615884
 
ENST00000616255
 
ENST00000620565
 
ENST00000622802
 
ENST00000624301
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UHRF1-001 ENSP00000478171
ENST00000620565
B4E0F9
Show all »
Show » Show » 857 96.6 No 0
UHRF1-002 ENSP00000480214
ENST00000613817
B4E0F9
Show all »
Show » Show » 496 55.1 No 0
UHRF1-003 ENSP00000479617
ENST00000622802
B4E0F9
Show all »
Show » Show » 806 91.1 No 0
UHRF1-004 ENSP00000478348
ENST00000616255
Q96T88
Show all »
Show » Show » 793 89.8 No 0
UHRF1-005 ENSP00000478601
ENST00000615884
Q96T88
Show all »
Show » Show » 793 89.8 No 0
UHRF1-006 ENSP00000484739
ENST00000612630
Q96T88
Show all »
Show » Show » 793 89.8 No 0
UHRF1-201 ENSP00000485604
ENST00000624301
B4E0F9
Show all »
Show » Show » 793 89.8 No 0