GRIN2B

GENE INFORMATION

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Gene name

GRIN2B (HGNC Symbol)

Synonyms

GluN2B, NMDAR2B

Description

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B (HGNC Symbol)

Entrez gene summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.1

Chromosome location (bp)

13537337 - 13980119

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000273079 (version 78.38)

Entrez gene

2904

UniProt

Q13224 (UniProt - Evidence at protein level)

neXtProt

NX_Q13224

Antibodypedia

GRIN2B antibodies
 

PROTEIN VIEW

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GRIN2B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIN2B-001 ENSP00000477455
ENST00000609686
Q13224
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