HIST2H4B

GENERAL INFORMATION

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Gene name

HIST2H4B

Gene description

Histone cluster 2, H4b

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression, most abundant in proliferating cells.

ANTIBODY RELIABILITY

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Data reliability
description

Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Data reliability

Supportive based on 1 antibody.
HPA042201
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

HIST2H4B (HGNC Symbol)

Synonyms

H4/o

Description

Histone cluster 2, H4b (HGNC Symbol)

Entrez gene summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q21.2

Chromosome location (bp)

149854045 - 149861210

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000270276 (version 78.38)

Entrez gene

554313

UniProt

P62805 (UniProt - Evidence at protein level)

neXtProt

NX_P62805

Antibodypedia

HIST2H4B antibodies


PROTEIN BROWSER

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ENST00000579512
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIST2H4B-004 ENSP00000462355
ENST00000579512
P62805
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