CGB1

GENE INFORMATION

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Gene name

CGB1

Synonyms

Description

Chorionic gonadotropin, beta polypeptide 1 (HGNC Symbol)

Entrez gene summary

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

49035610 - 49036895

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000267631 (version 78.38)

Entrez gene

114335

UniProt

A6NKQ9 (UniProt - Evidence at transcript level)

neXtProt

NX_A6NKQ9

Antibodypedia

CGB1 antibodies
 

PROTEIN VIEW

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CGB1-001
 
CGB1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CGB1-001 ENSP00000301407
ENST00000301407
A6NKQ9
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Show » Show » 155 16.7 Yes 0
CGB1-002 ENSP00000472896
ENST00000601167
K7ELM3
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Show » Show » 130 14 No 0