HP

GENE INFORMATION

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Gene name

HP

Synonyms

Description

Haptoglobin (HGNC Symbol)

Entrez gene summary

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Chromosome

16

Cytoband

q22.2

Chromosome location (bp)

72054592 - 72061055

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000257017 (version 78.38)

Entrez gene

3240

UniProt

P00738 (UniProt - Evidence at protein level)

neXtProt

NX_P00738

Antibodypedia

HP antibodies
 

PROTEIN VIEW

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 « 
 
HP-001
 
HP-002
 
HP-003
 
HP-009
 
HP-011
 
HP-012
 
HP-014
 
HP-015
 
HP-016
 
HP-018
 
HP-019
 
HP-201
 
HP-202
 
HP-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HP-001 ENSP00000457629
ENST00000570083
P00738
Show all »
Show » Show » 347 38.5 Yes 0
HP-002 ENSP00000348170
ENST00000355906
P00738
Show all »
Show » Show » 406 45.2 Yes 0
HP-003 ENSP00000454966
ENST00000565574
P00738
Show all »
Show » Show » 347 38.5 Yes 0
HP-009 ENSP00000463491
ENST00000567612
Show » Show » 365 40.7 Yes 0
HP-011 ENSP00000463755
ENST00000569639
J3QQI8
Show all »
Show » 91 9.9 Yes 0
HP-012 ENSP00000350406
ENST00000357763
H0Y300
Show all »
Show » Show » 442 49.1 Yes 0
HP-014 ENSP00000456503
ENST00000564499
H3BS21
Show all »
Show » Show » 222 24.8 Yes 0
HP-015 ENSP00000454413
ENST00000562526
H3BMJ7
Show all »
Show » 92 10.2 Yes 0
HP-016 ENSP00000464070
ENST00000567185
Q6PEJ8
Show all »
Show » Show » 404 44.9 Yes 0
HP-018 ENSP00000462662
ENST00000568417
J3KSV1
Show all »
Show » 88 9.7 Yes 0
HP-019 ENSP00000461999
ENST00000576168
Show » 149 16.5 Yes 0
HP-201 ENSP00000228226
ENST00000228226
Q6PEJ8
Show all »
Show » Show » 281 31.4 No 0
HP-202 ENSP00000381199
ENST00000398131
P00738
Show all »
Show » Show » 347 38.5 Yes 0
HP-203 ENSP00000478279
ENST00000613898
Q6PEJ8
Show all »
Show » Show » 281 31.4 No 0