UGT1A4

GENE INFORMATION

? »

Gene name

UGT1A4 (HGNC Symbol)

Synonyms

HUG-BR2, UGT1D

Description

UDP glucuronosyltransferase 1 family, polypeptide A4 (HGNC Symbol)

Entrez gene summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

233718778 - 233773299

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244474 (version 78.38)

Entrez gene

54657

UniProt

P22310 (UniProt - Evidence at protein level)

neXtProt

NX_P22310

Antibodypedia

UGT1A4 antibodies
 

PROTEIN VIEW

? »
 
 
 
UGT1A4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT1A4-001 ENSP00000362508
ENST00000373409
P22310
Show all »
Show » Show » 534 60 Yes 1