UGT1A7

GENE INFORMATION

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Gene name

UGT1A7 (HGNC Symbol)

Synonyms

UGT1G

Description

UDP glucuronosyltransferase 1 family, polypeptide A7 (HGNC Symbol)

Entrez gene summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

233681938 - 233773299

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244122 (version 78.38)

Entrez gene

54577

UniProt

Q9HAW7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HAW7

Antibodypedia

UGT1A7 antibodies
 

PROTEIN VIEW

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UGT1A7-001
 
UGT1A7-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT1A7-001 ENSP00000362525
ENST00000373426
Q9HAW7
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Show » Show » 530 59.8 Yes 1
UGT1A7-002 ENSP00000420181
ENST00000485022
Q96DH9
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Show » Show » 157 17.9 No 0