NFS1

GENERAL INFORMATION

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Gene name

NFS1

Gene description

NFS1 cysteine desulfurase

Protein class

Enzymes
Mitochondrial proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A vast majority of tissues display granular cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA051801 , HPA054755 , CAB034314
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Bronchus

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NFS1 (HGNC Symbol)

Synonyms

IscS, NifS

Description

NFS1 cysteine desulfurase (HGNC Symbol)

Entrez gene summary

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

35668055 - 35699359

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244005 (version 78.38)

Entrez gene

9054

UniProt

Q9Y697 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y697

Antibodypedia

NFS1 antibodies


PROTEIN BROWSER

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ENST00000306750
 
ENST00000374085
 
ENST00000374092
 
ENST00000397425
 
ENST00000419569
 
ENST00000541387
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFS1-001 ENSP00000363205
ENST00000374092
Q9Y697
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Show » Show » 457 50.2 No 0
NFS1-003 ENSP00000363198
ENST00000374085
Q9Y697
Show all »
Show » Show » 397 44 No 0
NFS1-006 ENSP00000304740
ENST00000306750
Q8WV90
Show all »
Show » Show » 189 20.6 No 0
NFS1-009 ENSP00000380570
ENST00000397425
Q9Y697
Show all »
Show » Show » 397 44 No 0
NFS1-013 ENSP00000393482
ENST00000419569
A2A2M1
Show all »
Show » Show » 108 12.2 No 0
NFS1-017 ENSP00000440897
ENST00000541387
Q9Y697
Show all »
Show » Show » 406 44.4 No 0