GSTA1

GENE INFORMATION

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Gene name

GSTA1

Synonyms

Description

Glutathione S-transferase alpha 1 (HGNC Symbol)

Entrez gene summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.2

Chromosome location (bp)

52791664 - 52803910

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000243955 (version 78.38)

Entrez gene

2938

UniProt

P08263 (UniProt - Evidence at protein level)

neXtProt

NX_P08263

Antibodypedia

GSTA1 antibodies
 

PROTEIN VIEW

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GSTA1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GSTA1-001 ENSP00000335620
ENST00000334575
P08263
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